Hearing loss in early adulthood and deafness are caused by a mutation in a gene related to hearing. Scientists at the Scripps Research Institute (TSRI) recently determined that a single gene is responsible for our audience. They have also discovered that the exact cause of deafness while suggesting new avenues for therapies hearing.
mutant gene Tmie can cause deafness, hearing loss in adulthood
The TSRI study, published in the journal Neuron, reveals how mutations in a gene called Tmie can cause deafness from birth right or decreased hearing in recent years.
The researchers were able to examine the ciliated cells called knockout mice, using electrophysiological techniques more than six months. They reintroduced the Tmie gene in the population before bringing back the same process that reinforces the hearing. That means that one day you might be able to use gene therapy approaches to hearing loss.
Of course, scientists have long known that mutations in the gene Tmie could cause deafness, however, have never been sure how it could be.
Undoubtedly, the ear is complicated machinery. Basically mechanical changes sound waves into electrical signals to our brain to process the message.
When a sound wave enters the ear, the uneven tip – stereocilia – of hair cells in the inner ear are pushed back. Think of them as tiny blades of grass that are constantly bent by the wind. This type of movement creates tension on the strings of proteins that connect the stereocilia. This sends a signal to our brain.
However, this process of converting mechanical force into electrical activity – what is called mechanotransduction -. It is a mystery to researchers
mutation of genes and their role in hearing loss
Did you know that one of the most common birth defects is the loss or congenital deafness hearing? It is true.
Indeed, it affects about three out of every 1,000 children born. Genetic defects play a key role in congenital hearing loss, and this contributes to about 60 percent of deafness occurs in infants. Of course, genetic defects are not the only factor leading to hearing loss and deafness. Others may include trauma, environmental exposure, medical problems and medications.
So how genes work exactly? Well, in essence, they are a roadmap for the synthesis of proteins, which are the building blocks for everything in our body, such as hair, eyes, heart, lungs -. And ears
Each of us inherits half of all genes from one parent and half from the other. If some of these inherited genes are defective, a health disorder such as hearing loss or deafness can develop earlier or later in life, according to the American Academy of Otolaryngology.
research testing and detection of hearing loss
Over the past 10 years, advances in molecular biology and genetics have helped to better understand the development function and pathology of the inner ear. Researchers have identified several genes that underlie hereditary deafness and hearing loss -. In particular, the mutation of GJB2
As a result, screening for GJB2 gene are available to people so they can determine their risk of having a child with hearing problems.
Now that researchers have learned how mutations in the gene Tmie can cause hearing difficulties, the challenge is to find how many components of the mechanotransduction system take shape in the hair cells of the inner ear. In the future, we also need to understand the biophysical principles through which these same proteins mechanical signals into electrical become the first place.
I will only give more hope to those who are hearing impaired.
we’ve all accepted that as we age, things just do not work the same way it used – including audience. Many of us just expect to hear to fade and simply believe that there is nothing we can do about it. But hearing loss must not be a normal part of aging. In fact, there are steps that can be taken in order to protect your valuable audience. Continue reading …
We all know that years of loud noises can contribute to hearing loss. Family history, head trauma, illness, and even simply aging can contribute to hearing loss. But there is a surprising connection between a common disease and hearing loss may not have been familiar. Continue reading …
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