Vitamin B3 compound could help prevent hearing loss

Natural Health News – Researchers have found a way to prevent induced hearing loss noise using a simple chemical compound that is a precursor of vitamin B3 (niacin).

This discovery by scientists at Weill Cornell Medical College and the Gladstone Institutes has important implications for the prevention of hearing loss.

In a study published in the journal Cell Metabolism , the researchers used the nicotinamide riboside chemistry (NR) to protect nerves in the cochlea. The cochlea, or inner ear, sound information transmitted through these nerves along a path to the brain. Exposure to loud noise can damage the synapses that connect nerve and hair cells of the cochlea, resulting in hearing loss induced by noise.

Researchers in laboratory animals exposed to avoid this nerve damage, giving mice NR before or after exposure to loud noises. NR was successful in preventing damage to the synaptic connections, avoiding short-term hearing loss and long term both. What is more, NR was equally effective whether administered before or after noise exposure.

“One of the major constraints in the management of inner ear disorders, including hearing loss, is that there is a very limited treatment options number. This discovery identifies a unique path and a potential drug therapy treat hearing loss induced by noise, “says Kevin Brown, MD, PhD, associate professor of otolaryngology-head and neck surgery at the University of North Carolina School of Medicine and one of the authors of the teacher.

The researchers chose NR, since it is a precursor chemical compound nicotinamide adenine dinucleotide (NAD +) which had previously been shown to protect nerve cells from injury cochlea.

Beyond the prevention of hearing loss, the researchers believe that the results may have wider applications because the underlying form NR protects nerve cells. Scientists demonstrated that NR and NAD + preventing hearing loss by increasing the activity of the protein sirtuin 3 (SIRT3), which is critically involved in mitochondrial function, power plants of the cell.

SIRT3 decreases naturally with age, which could partly explain hearing loss associated with aging. In addition, some people have different variations of genes SIRT3 resulting from reduced enzymatic activity, which makes them more susceptible to hearing loss induced by noise.

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