Alzheimer’s is a progressive brain disorder that leads to memory loss and can seriously affect a person’s ability to perform daily tasks. Salk Institute scientists have found evidence that (THC) tetrahydrocannabinol compounds found in marijuana may promote cell elimination of beta amyloid protein in the brain -. brain plaques which are related to the progression of Alzheimer’s disease
This shows the study?
Alzheimer’s disease affects more than five million Americans according to the National Institutes of Health, and is a leading cause of death. It is also the most common cause of dementia and its incidence is expected to triple over the next 50 years. It is strongly associated with the accumulation of beta-amyloid proteins in the brain, forming plaques that are believed to somehow damage neurons and cause its demise. As a result, the key regions of the brain like the hippocampus may decrease in volume, resulting in serious defects in learning and memory.
How it works?
The compound works by passing from the lungs to the bloodstream, where it binds to two types of receptors, cannabinoid receptors (CB) 1 and 2, found on the surface of cells throughout the body.
receptors in the brain can be activated by endocannabinoids, which are a class of molecules made in the body that signal between brain cells. THC works similarly to endocannabinoids manner by activating the same receptors in the brain, resulting psychoactive effects of the drug.
“ Inflammation in the brain is a major component of the damage associated with Alzheimer’s disease, but always assumed that this response was from immune cells and in the brain, not the nerve cells themselves, “first author Antonio Currais, a postdoc in the laboratory of Schubert researcher, said in the statement .
The researchers found that high levels of beta amyloid associated with cellular inflammation and higher rates of death of neurons. They demonstrated that exposure of cells to THC reduces levels of amyloid beta protein and eliminated the inflammatory response of nerve cells caused by the protein, thereby allowing cells to survive nerve.
What they found was that not only the THC causes a breakdown of the accumulation of the protein, but a reduction in inflammation in cells. Inflammation is bad, because it makes it more difficult for neurons to communicate with each other properly.