Yet another boost for acceptance of cannabis as a cure wonderful! While there have been investigations and trials of using the compounds to treat chronic pain, cancer, epilepsy and other diseases and ailments, this laboratory study is the first of its kind to test the tetrahydrocannabinol (THC), a major component of marijuana, against plaque accumulation brain associated with Alzheimer’s disease.
Alzheimer’s disease can now be added to a list of diseases promising treatment from compounds of cannabis, a new study says Salk Institute.
In the study, researchers cultured human neurons in a laboratory and created altered so that plaque accumulation associated with Alzheimer’s disease. The plate consists of proteins, such as beta-amyloid. The researchers subjected laboratory neurons grown to concentrated amounts of THC and other compounds of marijuana.
What they found was that not only the THC causes a breakdown of the accumulation of the protein, but a reduction in inflammation in cells.
Inflammation is bad as communication between neurons becomes more difficult.
“Although other studies have provided evidence that cannabinoids may be neuroprotective against the symptoms of Alzheimer’s disease, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and accumulation of beta amyloid in nerve cells, “says Salk professor David Schubert, the lead author, said in a statement.
Research also suggests that these is a strong link between protein buildup and inflammation of neurons. Some earlier theories had thought that other immune cells, as they had inflamed, not the neurons themselves.
Researchers believe that the compound THC was able to reduce protein buildup and inflammation by working on receptors in the brain endocannabinoids (which occur naturally in the human body). Scientists already knew that exercise these receptors is involved, and physical activity can slow the progression of Alzheimer’s disease.
Schubert and his fellow researchers had found in a previous study that endocannabinoids receptors had to do with the removal of protein buildup and inflammation when testing a new drug. Then the researchers decided to investigate the relationship with the THC and Alzheimer plate.
must be carried out before a definite link can be suggested between THC and amyloid beta
Many more studies, researchers say. Clinical trials in humans is the next step in the quest to eradicate and control this degenerative disease. These exploration laboratory models are just the beginning.