Scientists probe green tea’s protective effects in pancreatic cancer

Natural Health News – Green tea and its extracts have been widely promoted as possible treatments for cancer and several other diseases.

However, although scientific data has demonstrated this protective effect, scientists have struggled to explain exactly how it works to reduce the risk of cancer or slow the growth of cancer cells.

Now, a study published recently in the journal metabolomics offers an explanation that researchers say could open a new field of research to combat cancer.

The disruption of the metabolism of cancer cells

The study reports that epigallocatechin-3-gallate (EGCG), the biological active constituent in green tea, it changed metabolism of cells of pancreatic cancer by suppressing expression of lactate dehydrogenase enzyme-a (LDHA) high levels of which are associated with cancer.

The researchers also found an inhibitor of the enzyme, oxamate, which is known to reduce LDHA activity operated in the same way. It also interrupts the metabolic system cells of pancreatic cancer

Wai-Nang Lee, MD, author of the study and a Biomedical Research Institute of Los Angeles (LA BioMed) principal investigator, which corresponds explains:

“scientists had believed they needed a molecular mechanism to treat cancer, but this study shows that they can change the metabolic system and have an impact on cancer. ”

“In explaining how green the active component tea could prevent cancer, this study will open the door to a whole new area of ​​cancer research and help understand how other foods can prevent cancer or delay growth of cancer cells. ”

A new way of looking at cancer

Using sophisticated methods of metabolic profiles, researchers found EGCG alters the balance of “flow” through cellular metabolic network.

Flux is the rate of rotation of molecules through a metabolic pathway. The researchers found that EGCG disrupts this balance oxamate the same way, a known inhibitor LDHA, did.

Based on this finding, it was concluded that both EGCG and oxamate reduce the risk of cancer by suppressing activity LDHA, a critical enzyme in the metabolism of cancer, thereby altering the balance cancer cells metabolic functions.

“This is a completely new way of looking metabolism,” said Dr. Lee. “It is not a case of glucose into and out of energy. Now we understand how the metabolism of cancer cells can be disrupted, and we can examine how we can use this knowledge to try to alter the course of cancer or prevent cancer . “

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