Scientists have made a revolutionary discovery in the understanding of multiple sclerosis (MS), a disease that attacks the central nervous system. In a study published in Frontiers in Neurology , researchers at the University of Surrey have found a misfolded, or protein “criminals” in MS. This finding indicates that MS has more in common with Parkinson’s, Alzheimer’s and ALS than previously recognized, as previous research has shown a similar rogue protein plays a role in these diseases. They hope this discovery will lay the foundation for greater knowledge about MS, and new treatments for neurodegenerative diseases.
In this latest study, scientists from the University of Surrey, University of Texas Medical Center and PrioCam laboratories were able to create unique molecules, called antibodies, to fight these proteins unscrupulous. There was an unexpected development when these antibodies were also able to recognize rogue proteins in Creutzfeldt-Jakob disease, along with neurodegenerative disorders associated with other molecules.
The team initially was working to develop a diagnostic test that would reveal Alzheimer’s disease before a person experiences obvious symptoms. They developed antibodies that bind to proteins that are unscrupulous disease characteristics.
The use of these antibodies to investigate the possibility that criminals proteins were present in brain tissue and cerebrospinal fluid of patients with multiple sclerosis, the researchers concluded that MS may also be the result of a protein adopts a permanent criminal state.
Dr. Mourad Tayebi at the University of Surrey said:
Multiple sclerosis is a major health burden, which affects the quality of life of many people. Our discovery suggests a new and alternative way to carry out research into multiple sclerosis, by, first, identifying a clear link with other neurodegenerative diseases. The results are important in redefining the molecular and cellular makeup of these diseases, and provides an important step in the search for a laboratory test milestone and an effective cure.
Dr. David Monique de PrioCam is the co-author of the study. She summed up the significance of the findings, saying the investigation indicates that these proteins criminals “share a common structure and may share similar pathogenic mechanisms.” This research has conclusively linked the existence of misfolded proteins to multiple sclerosis.