Opdivo is a drug that has been recently approved by the FDA for the treatment of lung cancer. Find out all you need to know about Opdivo and treatment of lung cancer today, in our opinion.
What is Opdivo?
Opdivo is a drug that was approved by the FDA in March 2015 to treat a specific type of lung cancer.
Opdivo is the brand name of the generic nivolumab.
The FDA approval for Opdivo is a big problem: the FDA approved Opdivo months earlier than expected. approval of the drug was accelerated based on the speed with which has improved survival rates.
Some news discussed how Opdivo was approved by the FDA for the comprehensive treatment of all types of lung cancer. In reality, however, the drug was approved only for patients with a very specific type and stage of the disease.
“… the approval of the FDA was Opdivo for patients only a very specific type and stage of disease :, cancer non-small cell lung squamous cells that have already metastasized and offer already resistant to platinum-based chemotherapy (such as cisplatin, carboplatin, or oxaliplatin). This is only a small percentage of patients living with lung cancer. ”
How does Opdivo to treat lung cancer? Let’s take a closer look to this drug.
How Opdivo work?
Opdivo, like many emerging cancer drugs on the market, works as an immunotherapy drug or immuno-oncology.
Traditional cancer treatments have focused on the elimination of cancer cells. Modern cancer treatments as Opdivo, however, are designed to help normal functioning immune system of your body more effectively so that your body can kill cancer cells way.
Opdivo belongs to a specific class of inhibitors drugs called immunotherapy control point. These drugs are called inhibitors checkpoint because they use a function in the body’s immune system is called “control points”. positions natural control of your body prevent immune cells from attacking everything.
Checkpoints are like guards that selectively allow immune cells through a battlefield. If the immune cells have a legitimate reason to go to fight on the battlefield (as a foreign invader they need to fight), the checkpoint guards to let go.
Without checkpoints, immune cells fight everything in your body. When your immune system fights everything in your body, you have an autoimmune disease (such as lupus).
Tumors often spread because they trick the body’s immune system by producing proteins that activate the security checkpoint. The checkpoints do not allow immune cells through fighting tumors because checkpoints believe that tumors are natural parts of the body. This allows cancer to grow and spread.
Control tumors trick posts by producing a protein called PD-L1. These proteins bind then then bind to a protein in immune cells called PD-1. When these two proteins bind together, the checkpoint is activated and prevents the immune system from doing its job.
Opdivo works by inhibiting checkpoints in your body. Opdivo binds to PD-1, preventing PD-1 from binding to PD-L1, which suppresses functionality checkpoint-beat tumor.
Opdivo is not the only drug using this mechanism. Other drugs such as oil and Keytruda YERVOY checkpoints destination on your immune system.
How effective is Opdivo?
immune therapy drugs do not work in all patients with cancer. However, they are shown to be particularly effective for patients with lung cancer -. Especially those with the right mutation
lung cancer patients seem to respond particularly well to immuno-oncology drugs. They have a greater rate than patients with other cancers success. Opdivo, for example, it has a success rate of 15%.
may seem low, but researchers are praising the drug because 15% of patients affected by Opdivo, the results of the drug are “durable”, which means they last for a long time.
Approximately 60% of patients had a response to Opdivo were still responding to the drug six months later. Meanwhile, other cancer therapies can quickly lose their effectiveness over time.
A success rate of 15% may not seem very high, but Opdivo however, is being hailed as a major step forward in the fight against lung cancer industry.
Opdivo Treatment Options
Opdivo was approved by the FDA in March 2015 as a treatment for a specific type of lung cancer. However, the official website Opdivo claims that the drug can be used to treat a variety of conditions, including:
- Cancer -Lung
- -Kidney cancer
Opdivo Side Effects
“OPDIVO can cause the immune system to attack normal organs and tissues in many areas of your body and can affect the way they work system.”
This activity can lead to serious and potentially fatal diseases. Some of the side effects of Opdivo include:
Problems -Lung (pneumonitis). Symptoms include new or worsening sheepfold, chest pain and breathlessness
sites within problems (colitis ): This can result in cracks or holes in the gut, and symptoms include diarrhea, bowel movements than usual, blood in the stool, and severe pain in the stomach area or sensitivity
problems. liver (hepatitis): Yellowing of the skin or whites of the eyes are symptoms of hepatitis. You may also experience nausea or vomiting, pain in the right side of the stomach area (abdomen), drowsiness, bleeding or bruising more easily.
-Hormone gland problems: Opdivo can cause problems in the thyroid, pituitary, adrenal glands, pancreas and other hormonal glands. Signs and symptoms include headaches, extreme tiredness, weight gain or weight loss, dizziness or fainting, and changes in mood or behavior.
-Kidney problems: Opdivo can cause kidney problems as nephritis and renal failure, whose symptoms include a smaller amount of urine, blood in the urine, swelling of the ankles, and loss appetite [
-Skin problems :. Skin problems Opdivo include rash, itching, skin blisters and ulcers in the mouth or other mucous membranes
brain inflammation (encephalitis) :. Signs of this problem include tiredness, weakness, fever, headache, confusion, memory problems, drowsiness, seizures, hallucinations and stiff neck
-The problems in other organs :. Opdivo can also lead to changes in vision, severe or persistent muscle and joint pain and severe muscle weakness throughout the body
manufacturers Opdivo claim that these side effects may occur more frequently when used Opdivo in conjunction with YERVOY.
Talk to your doctor to see if Opdivo is the drug treatment of lung cancer right for your particular situation.