One of the worst disasters in the history of the drug is unfolding before our eyes.
DES (diethylstilbestrol) is a synthetic estrogen that was given to pregnant women from 1940 to early 1970. The DES is touted as a “drug wonder “that prevents involuntary abortion and morning sickness. It was only after millions of women and fetuses were exposed to DES was recognized that DES was causing deadly cancers, in women who took it and children exposed to it in utero. According to The Wonder Drug Movie , a documentary about DES:
The currently proven exposure effects include a rare vaginal cancer DES daughters; increased risk of breast cancer in DES mothers; possible risk of testicular cancer in DES sons; abnormal reproductive organs; sterility; high-risk pregnancies; and an increased risk of breast cancer in DES daughters after 40. There are a number of other suspects effects, including autoimmune disorders, but many of these effects are still pending further investigation.
DES is considered to be one of the worst disasters of the drug in human history. Deadly cancers, infertility and other health ailments that DES has caused have led to suffering, sickness and death of thousands of people. Although pharmaceutical companies responsible have paid settlements of millions of dollars that have never issued an apology or amounts sufficient to compensate the real damage done paid.
This video shows some of the effects of DES in women who were exposed to it in utero
the effects on future generations
Many of the effects of DES still feel today, because they are transgenerational – meaning that if a pregnant woman took DES 1950, his grandson may suffer from negative effects today. Due to the time lag between the drug and its effects time (many cancers take decades to appear in people who were exposed to DES in utero), and because of the difficulty of studying the transgenerational effects of drugs, many of the consequences of DES are only now being discovered. Note that transgenerational effects of drugs endocrine disrupting seem to intensify with each generation , and people suffering from infertility, cancer, reproductive problems, hormonal disturbances or autoimmune disorders should look at your family history for DES use .
Most research on the effects of DES has focused on DES daughters – women who were exposed to DES while in the womb – in part because one of the first effects of DES discovered was the appearance of a rare vaginal cancer called clear cell cancer in young women. Significantly less research has been done on children of DES -. Men who were exposed to DES in utero, while
endocrine disrupting Can Drugs Cause Transgender in utero?
Several researchers who have analyzed DES sons have indicated that a significant proportion of men exposed to DES in utero are either transsexual, transgender or intersex, and hypothesized that there is a connection between prenatal exposure to DES and gender variance.
This news WTSP in Tampa, Florida , explores the idea that exposure to DES in the womb may be responsible for gender variance later in life
Hugh Easton, a scientist and activist who identifies himself as having “an identity of unusual partially female gender” further explains gender differences and gender and how they can be affected by exposure to estrogen in the uterus (DES, and birth control pills used during pregnancy can have similar effects ). writes
What few people appreciate is that it is these very large differences between levels of male and female hormones throughout life that are responsible for all differences between being a man and a woman, not the X and the Y chromosome All sex chromosomes do is determine if you develop ovaries or testicles, is the fact that the ovarian tissue mainly produces estradiol while tissue testicular mainly produces testosterone which is responsible for people being organized in two distinct groups we call men and women.
There are two main stages of life when sex hormones, testosterone and estradiol, are active. The first is an ‘organic’ phase, which starts around 6 weeks after conception and ends a few months after birth. The second stage of life is puberty and adulthood, during which sex hormones have effects ‘activational’: bring to life everything that was established during the organic phase, and will turn a boy into a man or an adult woman.
A slight difference between the two phases is that during the organizational phase, testosterone and estradiol is the key hormone plays no role in sex determination. Whether you develop as male or female depends solely on whether the levels of testosterone (DHT and, a hormone derived from testosterone) are high or low. If the fetus or testes or ovaries develops, the result is a female baby. During the activational, you need high levels of testosterone in order to mature into an adult man, but in order to mature into an adult, you need high levels of estradiol. If no hormone is present, you can stay in an asexual, childlike state and never ripen properly in an adult.
Unfortunately, the idea that sex is determined by the X and Y chromosomes has become so deeply embedded in the popular consciousness that even most doctors and scientists who do not they work in the field are not aware that it is actually not the genes and hormones that determine sex. As a result, we ended up in a situation where, as a result of a gift given to their mothers during pregnancy (and medical treatment given to newborns) medical treatment, there are several million people at least alive today who were exposed hormone with testosterone blocking properties (or testosterone mimicking properties) during its organization. In theory, this should do what it is to produce people who have developed partly as male and partly as female, and judging what I’ve seen the effects of DES, which is in fact exactly what happens. It’s just that, as all their physical sexual characteristics develop within a relatively narrow time window during the first quarter, while increased use of high doses of hormones tends to occur during the second and third quarters, rather than cause physical abnormalities, is making people born who have experienced a stroke or intersex development-sexed opposite. The way this often manifests later in life is as transsexuality. Other effects (at least in exposure to DES in genetic males is concerned) it is that sperm counts are, on average, much lower than men not exposed, and it seems that there is a very high risk of developing also hypogonadism.
Hormones are so widely used in medicine that the number of people who have been affected must surely be very large, and I think those who have come out as transgender are likely to be only the tip of an even larger iceberg, people with psychological problems seemingly unrelated to gender caused by some of the regions of the brain that has developed as male and some as the female, or fertility problems and all kinds of mysterious chronic ailments they caused by their bodies are unable to regulate their hormone levels properly (this seems to be a very common side effect of these hormones also exposures).
Women who took DES during pregnancy often take doses that were up 50,000 times estrogen birth control pills today . Could exposure to such high levels of estrogen cause fetuses with XY (male) chromosomes to develop as females during some of the periods of organization of sexual development and gender? It certainly seems plausible.
Birth control pills also provide high doses of estrogen (hormones and others), and has also been hypothesized that birth control pills taken during pregnancy can also influence fetal gender expression. (For more information on this, please read the article by Hugh Easton, “ Treatment with hormones during pregnancy and gender variance in the elderly .”)
As more and more people transsexuals physically transition to gender, who identify with, it will become increasingly possible for researchers to explore possible connections between DES and / or exposure of the contraceptive pill in utero and the term transgender later in life. It is a hypothesis worth exploring -. Do not say that there is something wrong with men and transgender women, but to understand gender differences and gender in humanity, and to understand the biology and hormones and the world in which we live
Recognition of lawyers transgendered
transgender men and women have fought (struggling) hard to be recognized as equally valid and are entitled to basic rights of life, liberty and the pursuit of happiness as cisgendered people. They deserve to be treated as valuable human beings because they are human valuable, and hope to question how drugs that cause endocrine disruption may influence gender expression is not interpreted as trying to find something wrong or sick men and transgender women.
Note that many scientists, activists and concerned about making connections between DES and gender variance are themselves citizens transsexuals. Wanting to know why the genre itself is expressed as it is does not indicate a lack of self-recognition; rather, a restless mind follows, and hope you will encourage questions along these lines. We live in a world that is full of endocrine disrupting chemicals (pharmaceuticals synthetic hormone birth control, fluoride, fluorine-containing medicines, BPA, plastics, many pesticides and herbicides, etc.). It is reasonable to ask how these endocrine disruptors are affecting all areas of our lives -. Of cancers gender expression
I hope that trans people find this assumption to be liberating. If this hypothesis is correct, transgender people are as they are, not by choice, or even “just one of those things” which are as they are because the hormones determine the sex as much as chromosomes do, and exposure to the hormone changing chemicals during critical periods of development can alter gender.
I am a cisgendered, heterosexual woman, so maybe it’s not my place to write any of this. But personally, if an endocrine disruptor drug had influenced my gender identity, I want to know. Perhaps some in the transgender community feel the same way. The hypothesis that DES and other endocrine-disrupting chemicals (especially concentrates, such as birth control pills) are causing people to be transsexual should be explored, and perhaps knowledge can come empowerment.