More evidence of depression’s link with inflammation

Natural Health News – New research suggests that persistent inflammation in the body affects the brain in ways that are stubborn connected with symptoms of depression.

About one third of people with depression also have high levels of inflammatory markers in the blood, according to the study published in Molecular Psychiatry, these new findings strengthen the case that the form of high inflammation depression is different from other types and requires a different approach to treatment. What you need to know

Researchers have found that people with force to treat depression also suffer from inflammation.

This inflammation disrupts communication between key areas in the brain and in particular leads to a condition called anhedonia -. The inability to experience pleasure

The antidepressant treatment does not work for this type of depression, rather than measures to address inflammation are likely to be more successful.

pleasure swelling blocks signals

One of the main symptoms of strength for the treatment of depression is anhedonia, the inability to experience pleasure or an inability to derive enjoyment of everyday activities, such as food or time with family and friends.

“Some patients taking antidepressants continue to suffer from anhedonia” he says Jennifer says lead author Felger, PhD, assistant professor of psychiatry and behavioral sciences at the Faculty of Medicine and the Cancer Institute of Emory University Winship.

“Our data suggest that by blocking inflammation or its effects on the brain, which may be able to reverse anhedonia and help people with depression who do not respond to antidepressants.”

Looking deeper

Researchers analyzed 48 patients with depression measuring levels of CRP inflammatory marker (CRP) in the blood, and the use of brain MRI to deepen the function brain related to inflammation.

Part of brain imaging study, participants were not taking antidepressants, anti-inflammatory drugs or other medications for at least four weeks.

The results showed that high levels of CRP inflammatory marker (C-reactive protein) were linked to poor connectivity – essentially a “miscommunication” – as seen through brain imaging, between regions of the brain important for motivation and reward.

Blocking brain connectivity

In patients with high CRP levels, Felger and his colleagues observed a lack of connectivity between the ventromedial prefrontal cortex and the ventral striatum. In contrast, patients with low PCR had robust connectivity.

Elevated CRP levels were also associated with anhedonia reports of patients. Low connectivity between other region of the striatum and ventromedial prefrontal cortex was linked to a different symptom :. slow motor function, measured by finger tapping speed

A previous study of people with depression difficult to treat found that those with high inflammation (measured by PCR), but not to other participants in the study improved in response to the anti-inflammatory antibody infliximab . Together, these studies suggest that the fight against inflammation may be a way to approach difficult to treat depression.

New options for treatment

Felger says that his trial may lead to new therapies for the treatment of depression, anhedonia in high inflammation. She is, of course, talking about drug therapies.

However, other approaches such as acupuncture, dietary changes, body therapies and mind like mindfulness meditation versus sleep problems complementing the key nutrients like zinc and lutein have been shown to help reduce inflammation in the body and a more holistic approach to treatment can help reduce dependence on pharmaceuticals.

Of these diet is undoubtedly the most crucial. There is evidence that the shape of Western eating pattern – high in fat, sugar, salt and processed foods – directly leads to higher levels of inflammation in the body, while adopting a diet that focuses on healthy nutrition and high-quality fiber may help reduce inflammation .

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