High-dose vitamin C, benefits for ovarian cancer

Natural Health News – High doses of vitamin C administered intravenously with traditional chemotherapy, helped kill cancer cells, while reducing the toxic effects of chemotherapy for patients with cancer.

That’s the conclusion of scientists at the University of Kansas Medical Center. In a study involving the evaluation of cell therapy, animals and humans, the researchers found that a combination of vitamin C infused and drugs carboplatin conventional chemotherapy and paclitaxel stops ovarian cancer in the laboratory, and reduces toxicity associated with chemotherapy in patients with ovarian cancer.

The results of their study have been published in the journal Science Translational Medicine .

In the 1970s, ascorbate or vitamin C, was an unorthodox therapy for cancer. It was a safe place, and there were anecdotal reports of clinical efficacy when administered intravenously.

“But,” says the study’s lead author, Qi Chen, Ph.D., assistant professor in the Department of Pharmacology, Toxicology and Therapeutics and the Department of Integrative Medicine at KU Medical Center “after oral doses proved ineffective on two cancer clinical trials, conventional oncologists abandoned the idea. the doctors who practice alternative and complementary medicine continued to use it, so we felt more study was in order, “

” what we’ve discovered. “he continued,” is that, due to their pharmacokinetic differences, intravenous vitamin C, unlike oral vitamin C, kills some cancer cells without harming normal tissues. “

reducing the toxicity of conventional drugs

researchers clinical trial consisted of 27 patients with ovarian cancer stage 3 or 4 stage newly diagnosed. All participants received standard therapy with paclitaxel or carboplatin, while some were also treated with high-dose intravenous vitamin C researchers followed participants for five years. Those patients who received vitamin C tended to experience fewer toxic effects of chemotherapy drugs.

In laboratory mice, scientists found that vitamin C was able to kill cancer at concentrations achievable only cells by intravenous infusion, with no observable toxicity or pathological changes in the liver, kidneys or spleen .

When they saw what was happening at the cellular level, it was found that vitamin C surrounded by tumor cells that acts as a “pro-oxidant”, stimulating the formation of hydrogen peroxide, which kills cancer cells.

In a further investigation, the researchers found a number of mechanisms by which, acting as a pro-oxidant, vitamin C induced in cells of ovarian cancer, cell death including promoting damage to your DNA without affecting healthy tissue.

Strong evidence

High doses of vitamin C intravenously is currently administered to thousands of patients by practitioners of complementary and alternative medicine, explained one of the co-authors of the study, Jeanne Drisko, MD, director of the Integrative Medicine program. However, he notes, conventional doctors are skeptical about their therapeutic benefits. Given this bias current of thought, the researchers sought to understand more.

“The objective was to investigate the mechanisms of cell death vitamin C induced in the laboratory. And in patients with ovarian cancer, we conducted a clinical trial early examine the safety phase and toxicity of high-dose intravenous vitamin C. we now have a better understanding of the anticancer action of vitamin C, plus a clear safety profile and clinical and biological plausibility with a firm basis for proceeding, “

Drisko added. “Taken together, our data provide strong evidence to justify larger and more robust clinical trials to definitively examine the benefit of adding vitamin C to conventional chemotherapy.”

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