Natural Health News – For people with knee osteoarthritis add grapes to the diet it could be a simple way to reduce pain, improve joint flexibility and general mobility
These benefits, say researchers from the University of Texas Women can be attributed to the polyphenols found in grapes.
The research was presented before publication at the recent conference Experimental Biology 2014 in San Diego, California.
The clinical study of sixteen weeks, involved 72 men and women with knee osteoarthritis (OA) who were assigned to either consume grapes in the form of a lyophilized powder all the grapes, or placebo powder.
The results showed that both men and women who eat a grape-enriched diet had a significant decrease in the subjective perception of pain related activity and a general decrease in total knee symptoms. This beneficial effect was greater in women.
In addition, no differences related to age were observed: there was a 70% increase in the difficult activity for those under 64 years of age consuming the grape powder, while those receiving placebo had a significant decrease in this activity. Participants over 65 years if consumption of grapes or placebo, reported a decrease in moderate to difficult activities.
The different benefits for men
Evidence of increased metabolism of cartilage in men who consumed the grape-enriched diet; who had the highest levels of a major cartilage growth factor (IGF-1) than those treated with placebo. This protective effect was not seen in women.
The researchers noted that no difference was observed in the range of motion, either for grape group or placebo group. The serum marker for inflammation (IL-1-β) measured was increased in both groups of placebo and grape, although much less increase was observed in the group of grape.
“These results provide data promising that links the consumption of grape for two very important outcomes for people living with osteoarthritis of the knee: a reduction in pain and improved joint flexibility,” he said Shanil Juma lead researcher, PhD
“more research to better understand the results of serum biomarkers, as well as differences in age and gender observed is needed.”
also promising laboratory tests
In the presentation, Dr. Juma also shared the results of a recent study of cells that looked at the effects of grape polyphenols whole cell in cartilage integrity and markers cartilage health. cartilage cells were first treated with various doses of whole grape polyphenols, and then stimulated with an inflammatory agent. Cell proliferation increased significantly – in a manner dependent on the dose -. in the treated grape polyphenols in the presence of an inflammatory agent
In addition, a marker of cartilage degradation was significantly lower with the three higher doses of whole grape polyphenols compared with control cells and cells treated with the inflammatory agent, suggesting a possible protective effect of grapes in cartilage cells.
Osteoarthritis is a condition in which natural cushioning between the joints – cartilage – wear. the most affected areas include the hands, feet, spine, hips and knees.More of 8.5 million people in the UK have osteoarthritis, in the US more than 27 million people have the condition in both knees and more countries are affected area. Osteoarthritis is more likely to occur in people over 45 years of age, and women are more likely to suffer than men.