P Can I have a coffee after taking Synthroid?
A. Synthroid (levothyroxine) is absorbed best when taken on an empty stomach. Patients are advised to take first thing in the morning, but drinking coffee or eating breakfast less than 15 minutes after taking the pill can greatly reduce the amount of thyroid hormone entering the bloodstream ( European Review of Medicine and pharmacological Sciences , 2014; vol 18, pp 451-456 )
Synthroid and other tablets. levothyroxine not well absorbed by people taking the drug .. inhibitors acids known as proton-pump inhibitor (esomeprazole, lansoprazole, omeprazole, rabeprazole, etc.). It seems that gastric acid is needed to help the tablet dissolve in the stomach. A liquid formulation appears to have less disruption of these drugs ( Journal of Clinical Endocrinology and Metabolism , on the Internet on September 26, 2014 ).
Grapes, soy, papaya and dietary fiber can also reduce the absorption of levothyroxine. The usual advice is to wait at least one hour after taking Synthroid before you have your coffee or a meal.
Taken at bedtime
Some people find that taking the drug at the time, at least two hours after dinner, solve the problem ( Archives of Internal Medicine December 13, 2010).