Are Your Telomeres In Trouble?

life in the 21st century offers many luxuries. high-speed computers … cell phones … air conditioning and LCD TV. However, chemical solvents and industrial products that make them possible are poisonous. We are floating in a sea of ​​space-age ,, lab-created synthetic molecules. And they are flowing through the blood as you read this letter.

are part of life today, and we now have a new way to measure its effect.

One of the things that happened is the environment is causing their telomeres shorten.

I’ll give the example of the number one risk factor for heart disease -. High levels of homocysteine ​​ 1

elevated homocysteine ​​is a way to measure inflammation is going on inside your body that is being caused by all these foreign substances. elevated homocysteine ​​and then does more harm by blocking blood flow through your body and damage the lining of arteries.

And most doctors do not know anything about another damaging effect of elevated homocysteine. Shorten their telomeres.

high homocysteine ​​in the blood can triple the rate at which telomeres shorten. 2

One reason homocysteine ​​has such a detrimental effect on these small tips to make your DNA is that homocysteine ​​short telomerase.

Telomerase is the enzyme that the body uses to rebuild the telomere. So the environment in which it is giving a double whammy. First place homocysteine ​​shortened telomeres, then the enzyme the body uses to repair the damage is cut.

short telomeres are so common in people with heart disease who have critically short telomeres is now an independent risk factor for heart disease. 3

In a study published in the prestigious journal The Lancet , researchers found an association between short telomeres and atherosclerosis. 4 aging People with shorter telomeres had accelerated its blood vessels and had a buildup of plaque that correlates with the arteries that acted 8.6 years older.

This increased risk extends into every fiber of the heart muscle. In a study published in Journal of the American College of Cardiology , researchers found that people with heart failure had telomeres that were 40% shorter than normal. 5

elevated homocysteine ​​can cause strokes and heart attacks as well. 6

One way to tell if you are at risk is by getting your homocysteine ​​levels checked with a simple blood test from your doctor. Personally, I like to keep my patients levels at 7 or less.

The natural way to help keep your homocysteine ​​level in check and protect against heart disease is the ramp up their levels of vitamin B.

Vitamins B6, B9 ( also known as folic acid or folate) and B12 help convert homocysteine ​​to methionine, the good guy. B9 also restores the action of telomerase, counteracting the worst effect of homocysteine. 7

Methionine is one of the basic components of proteins. Without sufficient levels of B vitamins in your system, your body can not convert homocysteine ​​to methionine efficiently. This can lead to an overload of homocysteine ​​racing through his blood.

To increase your B vitamins, this is what I recommend:

Another way to convert homocysteine ​​to methionine is choline.

You may recall what I wrote to you about Hill as a brain stimulant. However, the hill is also essential in the process that breaks homocysteine ​​amino acids like methionine votes.

Studies show that the more hill that is, the lower the homocysteine ​​will be. 8 In one study, people who took the most choline homocysteine ​​had nearly 10% lower. 9

The best way to get over hill is eating a food “taboo” modern nutritionists say stay away from – animal meat and eggs. You can also find small amounts of choline in cod, cauliflower, avocados and bananas.

Complementing look choline citrate. In my opinion it is the best way to achieve high levels of choline, and no side effects. You need at least 425 mg of choline per day as a woman; 550mg if you are a man.

To your good health,
Al Sears, MD
Al Sears, MD

1. Levy D, Hwang S, et. Alabama. “Associations of plasma natriuretic peptide, adrenomedullin, and homocysteine ​​levels with alterations in arterial stiffness: the Framingham Heart Study,” Circulation 2007; 115 (24): 3079-85
2. Richards J, et. Alabama. “Homocysteine ​​levels and the length of leukocyte telomeres.” Atherosclerosis . . 2008; 200 (2): 271-7
3. Zhang W, R Hui, Yang S. “Telomeres, cardiovascular aging and cell senescence potential intervention.” Sci China Life Sci . . 2014; 57 (8): 858-62
4. Samani NJ, et al. “Shortening of telomeres in atherosclerosis.” Lancet . 2001; 358 (9280) :. 472-3
5. P van der Harst, et al. “Length of telomeres of circulating leukocytes decreased in patients with chronic heart failure.” J Am Coll Cardiol . 2007; 49 (13): 1459-1464
6. McCarty M, Thomas C. “The Vascular toxicity of homocysteine ​​and how to control it.” Linus Pauling Inst. Lpi.oregonstate.edu. Accessed November 6, 2014.
7. Zhang D, X Wen, Wu W, E Xu, Zhang Y, W. Cui “homocysteine-related DNA demethylation hTERT helps reduce telomere length of leukocytes in atherosclerosis.” Atherosclerosis . . 2013; 231 (1): 1739
8. Imbard A, et. Alabama. “Plasma choline and betaine correlate with folate in serum, plasma S-adenosyl methionine-S-adenosyl-homocysteine ​​in healthy volunteers.” Clin Chem Lab Med . . 2013; 51 (3): 683-92
9.Lee J, Jacques P, L Dougherty, Selhub J, Giovannucci E, S Zeisel, E. Cho “Are dietary choline and betaine intakes determinants of homocysteine total?” Am J Clin Nutr . . 2010; 91 (5): 1303-10

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