Many people today regularly take the bad cholesterol and lowering drugs apparently do not reduce the mortality rate specific to the heart disease in blood pressure.
However, a clinical trial that has been hidden for a decade has revealed a truth quite surprising. That is, their findings raise awareness of Granada’s ability to successfully restore health and save many patients with heart disease.
Namely, this study reported that:
“Consumption of juice Granada resulted in a significant reduction of IMT [intima media thickness], up to 30% after 1 year. ”
Therefore, there is growing interest in this beneficial fruit because it is completely natural and has no side effects, cheap and able to unclog arteries.
On the other hand, patients spend their money on expensive drugs, such as statins to lower cholesterol, which can not deliver positive effects and have been linked to more than more than 300 adverse health effects.
Namely, the media of the intima is, in fact, the middle of the arteries become inflamed and full of the plate composed of immune cells, oxidized fats, and his remains in the condition commonly known as “blocked arteries.”
As this part is made thicker, blood content have less room to move through the opening of the arteries (lumen). As soon as clogged arteries or closed, the person may suffer a disastrous injury or even death.
Therefore, anything that can reduce or prevent thickening of the intima-media in a natural way is very beneficial, so obtaining a resolution root cause of the atherosclerosis, and by implication can significantly prevent deaths related to cardiovascular mortality.
Therefore, since we are living in a world in which the leading causes of death is cardiovascular disease, and millions of patients use medications that only surrogate markers are reduced to the risk of cardiovascular disease, ie, lipoproteins that carry cholesterol without reducing heart disease or deaths, it is quite amazing how this potential has been neglected of Granada.
That is, if there is a slight chance that a simple intervention of this kind in the diet can reduce or reverse the main disease of millions of people around the world, it would be disastrous not use your potential.
Therefore, the objective of this article is to shed light on this trial and its results in order to focus on the importance of interventions based on foods as a way of prevent and even reverse the symptoms of the deadly disease of modern times.
Israeli researchers published their study in 2014 in Clinical Nutrition under the heading “Consumption of juice Granada for 3 years by patients with stenosis of the carotid artery reduces oxidation common carotid intima-media, blood pressure and LDL cholesterol, “ in its conclusions state that the Granada administered in the form of juice for a period of one year, reverse the buildup of plaque in the carotid arteries of subjects with severe stenosis but no symptoms, carotid artery (defined as 70-90% blockage in the internal carotid arteries).
This study included 19 patients, 5 women and 14 men, nonsmokers, at the age of 65-75. Ten of these patients consumed juice Granada, while 9 were in the control group and received placebo.
All participants had similar blood pressure, blood lipids and glucose concentrations, and took similar drugs involving the reduction of blood pressure (such as beta blockers, ACE inhibitors or calcium antagonists) and lipid-lowering drugs (such as statins).
Those ten patients received 1.69 ounces (50 ml) of juice Granada on a daily basis which included 036 milligrams of total polyphenols (mainly tannins and anthocyanins), for one year . Moreover, five of them decided to continue for up to three years.
Here are the results:
“The thickness of the intima-media media of arteries carotid right and left in patients common with stenosis severe carotid artery who consumed juice Granada up to 1 year dropped after 3, 6, 9 and 12 months of consumption of juice Granada by 13%, 22%, 26 % and 35%, respectively, compared with reference values ”.
If a drug has been shown to reverse the buildup of plaque in the carotid arteries by 13% in a period of only three months, which would have been considered a miracle and sold as a multibillion dollar blockbuster!
This is an impressive finding and whenever a factor in stenosis of the high carotid artery 9% in a year in the control group, the other group could have shown even better effects that demonstrated.
To be more specific, if patients in the group of Granada had received no treatment, thickening of the carotid arteries have progressed as in the case of the other group, at a rate of 9% per year, it ie 18% within 2 years, 27% in 3 years.
This indicates that after 3 years of treatment of Granada, thickening of the arteries would have been lowered by more than 60% beyond the actual situation in the case of natural progression of the disease.
The experts who conducted this study stated 3 possible mechanisms of action behind the anti-atherosclerotic activity Granada:
decreased blood pressure During the intervention, the researchers found a significant improvement in blood pressure in patients: systolic blood pressure was reduced by 7%, 11%, 10%, 10% and 12% after 1, 3, 6, 9, and 12 months of use of Granada, respectively, compared with the values measured before the investigation.
The ability of this fruit to lower systolic blood pressure shows that it has a healing effect on the endothelium, which is the inner lining of the artery that can not be completely relaxed in the case heart disease and leads to a condition called endothelial dysfunction.
Antioxidant properties :. Oxidative stress in patients in group Granada has been greatly reduced and the autoantibodies formed against ox-LDL, which is a form of oxidized low related density lipoprotein to the disease process of atherosclerosis
reduction of oxidative stress was measurable by an increase in paraoxonase blood serum enzyme 1 (PON1) up to 91% after a period of 3 years; PON1 is an enzyme having high activity is linked to a lower oxidative stress.
This is critical for the anti-atherosclerotic activity Granada due to hypothesize lipid peroxidation of atherosclerosis, suggesting that its cardiotoxicity / atherogenicity is not influenced by the amount only, but as well as the quality of blood lipids (ie, if oxidize / damaged or not).
What is most important is the fact that this amazing fruit prevents the effects of oxidative stress that lead to heart disease.
Plate Injury Stabilization: As 2 of 10 patients in PJ (after 3 and 12 months) experienced clinical deterioration, carotid surgery was done and injuries They were examined to determine the difference in composition to those who did not consume it this fruit. Therefore, the positive differences four different have realized:
-Lower cholesterol: “The cholesterol content in carotid lesions of the two patients who consumed PJ was lower by 58% and 20%, respectively, compared to lesions obtained from patients who did not consume CAS PJ (Fig. 3A) “.
Reduction of LDL oxidation: “LDL oxidation by injuries resulting from patients after consumption PJ for 3 or 12 months was significantly (Po0.01) decreased by 43% or 32%, respectively, compared to rates obtained for LDL oxidation CAS injury patients not taking PJ (Fig. 3D). “
-Increase reduced glutathione content: “a substantial increase in lesion reduced glutathione (GSH), (GSH is a major cellular antioxidant) 2, 5 times, was observed after PJ consumption for 3 or 12 months (Fig. 3C) “
Reduction of lipid peroxides. “ the lipid peroxide content in the lesions obtained from patients after consumption PJ for 3 or 12 months was significantly reduced by 61% or 44%, respectively, compared to the lesions of patients not taking PJ (Fig. 3B). “
These findings demonstrate that despite the ability of Granada to reduce the size of the injury in the carotid arteries,” injury itself may be considered less atherogenic after consumption PJ, as their cholesterol and oxidized lipid decreases, and from its ability to oxidize LDL was significantly reduced. “
Undoubtedly, this result is revolutionary, now, the threat of stenosis of the carotid artery is mainly considered by the size of the lesion and not for quality.
This is in accordance with the belief that the large amount of lipoprotein (ie, the “”) cholesterol in the blood may not accurately indicate whether these lipoproteins are dangerous (atherogenic), but if oxidized (eg, ox-LDL) which can be a threat (or representative of a more systemic imbalance in the body), while lipoprotein oxidized low density it can not be regarded as entirely benign, if not crucial to the heart and overall body health.
The researchers found that the group of Granada had elevated levels of triglycerides and very low-density lipoprotein, again, underscoring that anti-atherosclerotic properties possible have stronger connection improved quality with the physiological environment in which all lipoproteins operate their number.
Undoubtedly, all participants in the study took conventional care, based drugs for heart disease, such as blood pressure and cholesterol lowering drugs.
The results showed that Granada did not interfere with the drugs used, demonstrating that can be taken as a complementary / adjuvant therapy for those taking medications.
Moreover, the study found that the condition got worse gradually (for example, the average GIM rose 9% in a year), indicating that the drugs can not deliver results, and may even accelerate the development of the disease.