Akkermansia Muciniphila is a strain of bacteria in the gut that has recently shown promising results in loss studies of weight. Here’s our guide to everything you need to know about Akkermansia muciniphila and weight loss.
What is Akkermansia Muciniphila?
Akkermansia Muciniphila is a strain of intestinal bacteria that are believed to have antiinflammatory effects in humans. These anti-inflammatory effects appear to lead to better weight loss results.
Dozens of large studies have been done on gut bacteria so far. The first results are promising. Dozens more studies are underway to determine the amazing mechanisms behind this remarkable new intestinal failure.
In a study involving 49 adults with overweight and obesity, it was found that adults with the highest levels of Akkermansia muciniphila had better clinical measures after going on a diet. In the course of this study, these adults experienced a greater decrease in visceral fat than those who had lower levels Akkermansia muciniphila.
Other studies have indicated that Akkermansia muciniphila could also be used to treat diabetes or reduce the symptoms of diabetes.
The bacteria is naturally present in the human digestive tract in concentrations of 3-5%. However, these concentrations have been shown to drop with obesity.
How Akkermansia Muciniphila I work?
It is believed
Akkermansia muciniphila to work, as it has strong anti-inflammatory effects.
When this bacterium is present in the gut, these anti-inflammatory effects, basically, “calm” the digestive tract, which leads to health benefits through numerous areas of your body.
For example, some studies have shown an inverse relationship between Akkermansia muciniphila colonization and inflammatory conditions such as appendicitis or irritable bowel syndrome. In study , lower levels of Akkermansia muciniphila lead to an increased risk of appendicitis were observed.
Other studies have linked Akkermansia muciniphila to a lower risk of obesity and type 2 diabetes
Bacteria Akkermansia muciniphila to reduce obesity by increasing the thickness of the intestinal wall. Specifically, mucin added bacteria to the intestinal wall, increasing their thickness and preventing inflammatory compounds to be absorbed by the body.
Akkermansia Muciniphila and weight loss
Researchers are perhaps more excited to determine the effect it has on Akkermansia muciniphila weight loss.
In one study, researchers overfed mice containing three times more fat than a slimmer group of mice.
The obese group of mice were fed the bacteria Akkermansia muciniphila. Obese mice were able to reduce their fat load in half despite not change your diet in any way -. The only difference was the presence of Akkermansia muciniphila
In a separate study with obese mice, researchers fed mice diets varying in fat composition, but otherwise were identical. One group received lard, while the other received fish oil.
The results of this study were published in August 2015 . The researchers found that the group receiving the fish oil diet had increased levels of Akkermansia muciniphila and bacteria of the genus Lactobacillus. Meanwhile, the group of mice taking butter diet had lower levels of Akkermansia muciniphila and Lactobacillus.
The researchers took these results a step further by implementing the digestive bacteria in another group of mice that had been fed antibiotics to eliminate their existing digestive bacteria. All these mice were fed a diet of lard.
Although all mice received the same diet of lard, mice receiving bacteria donor oil fed fish showed increased levels Akkermansia muciniphila and reduced levels inflammation, while the opposite for the group of mice that received transplants fed lard mice was observed.
The researchers concluded that ultimately study indicating that an increase in Akkermansia muciniphila corresponded to a reduction in inflammation, indicating a relationship between dietary fat, the composition of the intestinal flora, and levels inflammation.
So Akkermansia muciniphila seems to work in mice. But what about in humans?
Well, in June 2015, researchers published a study of 49 adults with overweight and obesity and found that those with the highest levels of insect Akkermansia muciniphila had better clinical measures after going on a diet – . Including reducing visceral fat
Akkermansia Muciniphila and Brown Fat
Another study was published in Cell in December 2015 . That study indicated a link between Akkermansia muciniphila, brown fat, and weight loss.
white pillowy fat is the type of fat under the skin that stores excess calories and calories. Brown fat, however, is a healthier type of fat that generates heat, burning extra calories, and weight loss kickstarts.
Researchers are actively trying to determine the amount of white fat it becomes brown fat. In the study published in Cell, the researchers found that levels Akkermansia muciniphila change when mice are exposed to cold, and this can lead to the formation of brown fat. Here
The researchers subjected a group of mice in a special climate chamber for one month. That climate chamber with the increasingly cold weather. Meanwhile, a separate group of mice were maintained at room temperature as a control group.
As the mice grew colder, they lost weight. However, this effect was observed only for a few days. After a few days of adaptation, their bodies had adapted. The mice became best suited calories collecting their food because their intestines and the villi in the intestine became longer.
In other words, the cold temperatures had created a “supercharged gut, which got more calories than the same amount of food.”
The composition of intestinal bacteria in the cold group of mice also changed. Other benefits observed in the group of mice cold include the beige and brown fat, weight reduction and improved insulin sensitivity. These mice grew even long intestines.
to take further these results, the researchers then transplanted intestinal bacteria Mice cold weather in mice room temperature. Mice room temperature to enjoy the same benefits were observed.
“What was surprising is that mice transplanted with cold microbiota that had never been exposed to the cold before they were fully protected against hypothermia,” says study’s lead author Mirko Trajkovski . “Microbes alone was sufficient to induce this.”
The researchers finally identified the bacterial strain associated with these health benefits. They found that the benefits were linked to Akkermansia muciniphila.
Akkermansia Muciniphila and diabetes
Meanwhile, a study published in June 2015 indicated a relationship between Akkermansia muciniphila, insulin sensitivity, and healthy metabolic status in adults with overweight / obesity , which could pave the way for Akkermansia muciniphila use as a treatment for diabetes.
As mentioned above, the body increases insulin sensitivity as a survival mechanism in cold climates. Akkermansia muciniphila levels are growing in cold climates. It is for this reason that excited researchers about the implications of bacteria in diabetes research.
What this means for weight loss and you?
The last implication of all these studies Akkermansia muciniphila is that you can start watching diet pills Akkermansia muciniphila or “brown fat in a bottle” that are sold as nutritional supplements.
Basically, you are taking intestinal bacteria and put it into your own digestive tract to accelerate the process of weight loss and reduce inflammation.
However, researchers have warned that more research is needed – especially in human trials -. Before definitively can be determined between Akkermansia muciniphila and weight loss